LONDON, United Kingdom (AFP) — Barbora Krejcikova made a tearful Wimbledon exit as the defending champion crashed to a three-set defeat against Emma Navarro while Novak Djokovic powered to his 100th All England Club victory on Saturday.

Men's top seed Jannik Sinner crushed Pedro Martinez to reach the Last 16, but it was the contrasting fortunes of Krejcikova and Djokovic that took the spotlight.

Krejcikova appeared to be struggling with injury as she wept in the closing stages of the third-round clash on Court One. Navarro took advantage to cause the latest upset in the women's tournament following the exits of five of the top six seeds.

Krejcikova had to fight back from a set down to beat rising star Alexandra Eala in the first round before another tense three-set win over Caroline Dolehide in the second round.

There would be no dramatic escape for Krejcikova this time, with the 17th seed's fitness problems finally catching up with her against American 10th seed Navarro.

Krejcikova, a two-time Grand Slam champion, has endured a difficult time since defeating Italy's Jasmine Paolini in the Wimbledon final last year.

She was out of action until May after suffering a back injury and losing in the second round of the French Open.

Krejcikova also pulled out of the recent Eastbourne Open before the quarter-finals with a thigh problem.

"I was definitely enjoying myself and I was feeling quite well. Suddenly out of nowhere, I just lost all my energy and I couldn't really gain it back," Krejcikova said.

"I was actually feeling worse and worse with time. It's very sad for me and very unfortunate."

Djokovic reached his landmark century by demolishing Serbian Davis Cup teammate Miomir Kecmanovic 6-3, 6-0, 6-4 in one hour and 47 minutes on Centre Court.

The 38-year-old Serb's 100-win tally at the All England Club is only surpassed by eight-time champion Roger Federer, who won 105 times, and Martina Navratilova, who chalked up 120 victories.

"It's very historic. It sounds very nice. I am very grateful to be in this position," said Djokovic, who persuaded his daughter to perform his post-match “pump it up” celebration from the players' box.

"Wimbledon is a favorite tournament and a dream for so many players. Any history I make at my favorite tournament, I'm blessed."

He is in the fourth round for the 17th time in his 20th appearance at Wimbledon and will face Australian 11th seed Alex De Minaur, who beat Denmark's August Holmgren in three sets.

Djokovic is chasing a record-breaking 25th Grand Slam crown as the seven-time Wimbledon champion looks to break his tie with the long-retired Margaret Court.

Sinner, who could face Djokovic in the semi-finals, took just one hour and 55 minutes to rout 52nd-ranked Martinez 6-1, 6-3, 6-1 in a Centre Court masterclass.

The 23-year-old Italian next plays Bulgarian 19th seed Grigor Dimitrov, a straight-sets winner over Austria's Sebastian Ofner.

Sinner has lost just 17 games across his first three matches at this year's tournament, equalling the previous lowest Open era total of games dropped to reach the last 16 in the men's event set by Jan Kodes in 1972.