NEW YORK (AFP) — US women's college basketball sensation Caitlin Clark scored 41 points as the University of Iowa avenged its defeat to Louisiana State University (LSU) in last year's national championship showdown with a 94-87 victory on Monday.

Clark, the all-time leading scorer in the history of collegiate basketball, produced a stunning exhibition of long-range shooting to lead the Hawkeyes into the Final Four of the tournament known as March Madness.

The 22-year-old prodigy, who is playing her final season of college basketball before heading into the Women's National Basketball Association, drained nine three-pointers with a scintillating performance at the MVP Arena in Albany, New York.

"This one feels a little bit better," Clark said after Monday's win.

"It's my senior year with this group, and a lot of people counted us out at the beginning of the year."

"And all we did was work really hard. But the job's not yet done."

Anticipation for Monday's game had dominated the US sporting headlines in the build-up, shoving the NBA, baseball and ice hockey out of the spotlight ahead of a game that was broadcast in primetime on ESPN.

Clark set the tone for an absorbing battle against old rival Angel Reese after nailing the opening score of the night with a trademark three-pointer.

LSU star Reese threatened to end Clark's college career on a downbeat note after helping the Tigers rally back from an early 12-4 deficit to open up an eight-point lead in the second quarter.

But Clark led a stirring Iowa fightback to help level the score 45-45 at half-time before cutting loose after the restart to help the Hawkeyes surge into an 11-point 69-58 lead at the end of third quarter.

Clark rattled in four of her three-pointers in the third quarter to help take the game away from LSU and stay on track for a fairytale ending to her collegiate career.

"I think just confidence, being confident in all the work that I put in, trusting my teammates," Clark said of her third quarter scoring spree.