Third seed Daniil Medvedev and 2022 finalist Stefanos Tsitsipas powered into the Italian Open semi-finals on Thursday with comfortable straight-set wins.

Medvedev continued his clay breakthrough as he reached the final four 6-2, 6-2 over Yannick Hanfmann.

Greek Tsitsipas, the 2022 finalist,  subdued Croat Borna Coric 6-3, 6-4 on a day when the French Open field was blown wide open by the withdrawal of Rafael Nadal.

The iconic 14-time champion, 36, cast a huge shadow over his future in the game, confessing that he did not know when he would be fit from a hip injury which has kept him off court since January.

Medvedev, the 2021 US Open champion, has made big improvements in his clay game here after freely admitting he's never been comfortable on the dirt.

He has shattered that stereotype with his steady progress at the Foro Italico, reaching his seventh semi-final of the season. Medvedev dominated number 101 German qualifier Hanfmann after settling in following breaks of serve in the opening three games in their quarter-final.

After going down a break in the second set, the 31-year-old Hanfmann complained to his coaching box that he had no legs left as he played on prior to losing serve for the fifth time in the match.

But he struck back briefly with a break of the seed to hold on for 2-4 before dropping serve again as Medvedev moved into winning position, closing it out on a second match point.

"All of the courts are pretty different here, it was not easy to adapt for both of us," Medvedev said.

"But I managed to adapt better. I'm really happy about it. A win is a win. Not counting the serve, I played well, returned well, moved well.

"I'm looking forward to the next round."

Prior to this edition, Medvedev had never won a match in Rome and had little confidence in his game on the clay. He is now into the final four after four victories and the loss of just one set.