Osaka is yet to drop a set across her opening four matches at Wimbledon.
Seeded 14th, she is finally finding her groove on grass, helped by the eye-catching outfits she arrives on court wearing.
Her walk-on costumes have included a kimono, a bomber jacket with a long train and a cloak that looks like an open kimono.
Once again the 28-year-old treated fans to a memorable outfit before delivering a tailor-made performance that left Sabalenka's Wimbledon challenge in tatters in the Last 16.
Osaka faces Czech 10th seed Karolina Muchova, who eliminated former Wimbledon champion Barbora Krejcikova in the fourth round, for a place in the semifinals.
For me this court is so special. This is the first match I've won on this court. It means a lot," Osaka said.
"It's been a long time since I've had so much fun on the court and to do it here, really means a lot."
Sabalenka's bid for a 15th consecutive Grand Slam quarter-final came to an abrupt halt.
She bows out of a major tournament before the quarter-finals for the first time since the French Open in 2022.
She had lost in the semi-finals on each of her past three visits to Wimbledon and has never made the final.
"I just want to go, get completely drunk, forget about tennis, and try to get in better shape," Sabalenka said.
World No. 1 Sinner eased past 151st-ranked Mochizuki to set up a quarterfinal tie with German veteran Jan-Lennard Struff.
"I tried to stay aggressive. I had some chances in the second set and couldn't use them, but I'm still very happy, trying to step up the level as we go," the four-time Grand Slam champion said.
Struff became the oldest first-time men's Grand Slam quarter-finalist in the Open era after Hubert Hurkacz retired injured during the fifth set of their Last-16 tie.