"President Biden is one of America's most respected and influential voices in national and global affairs," said Richard Lovett, co-chairman of CAA, praising the former leader's "commitment to public service."
"We are profoundly honored to partner with him again."
Biden had published his memoir, Promise Me, Dad, and launched a book tour that sold more than 85,000 tickets nationwide during his previous stint with CAA, the agency said.
One of the world's largest talent agencies, CAA's roster ranges from actor Meryl Streep and lifestyle mogul Martha Stewart to Japanese baseball star Shohei Ohtani.
According to trade publication Variety, it also represents the production company Higher Ground — fronted by Biden's former boss, ex-president Barack Obama and his wife Michelle.