"You have achieved what was thought impossible," Macron told workers and officials who packed Notre Dame after the French president toured the cathedral.
"The blaze at Notre Dame was a national wound, and you have been its remedy through will, through work, through commitment," he said, adding the cathedral's re-opening will be a "shock of hope."
"This is an immense source of pride for the entire nation," Macron said, expressing hope that the spirit of "fraternity" would endure.
Notre Dame will welcome visitors and worshippers again over the December 7-8 weekend, after a sometimes challenging restoration to return the imposing Paris cathedral to its former glory after it was badly damaged by fire on 19 April, 2019.
World leaders are expected to attend but the guest list has yet to be revealed.
The French president is hoping the re-opening of Notre Dame will be a major feather in his cap amid the current political deadlock following early parliamentary elections this summer.
"We were told many times at the beginning that it wouldn't be possible, that it was crazy, that it was arbitrary, that we were going to do it wrong," Macron said.
"But in the end," he added, "you did it."