World number two Daniil Medvedev was knocked out of the French Open in the first round on Tuesday, losing in five sets to 172nd-ranked Thiago Seyboth Wild of Brazil as Roland Garros attempted to move on from Novak Djokovic's Kosovo controversy.

Seyboth Wild, who came through the qualifiers and had never previously won a Grand Slam match, triumphed 7-6 (7/5), 6-7 (6/8), 2-6, 6-3, 6-4.

It was Medvedev's fifth loss in the opening round at Roland Garros in seven appearances.

"It's a dream come true to beat these kinds of players on this court," said the 23-year-old Brazilian who unleashed 69 winners on Court Philippe Chatrier.

"I was cramping in the second set and couldn't really serve the way I wanted but I tried to play my best tennis."

Seyboth Wild, without a win on the main tour since February 2022, held his nerve in the conclusion of the four-hour 15-minute match, one of a Grand Slam record 21 first-round ties to require five sets.

He twice saw breaks retrieved by Medvedev in the deciding set before finally backing up a third break with a hold for 5-3. Two giant forehands secured victory.

Medvedev arrived in Paris buoyed by winning his first-ever clay court title at the Italian Open last week for his fifth trophy of 2023.

"Every time the clay court season finishes, I'm happy," said Medvedev.

Djokovic will return to Court Philippe Chatrier on Wednesday night for his second-round match with controversy over his "Kosovo is the heart of Serbia" message still raging.

The Belgrade-born superstar, chasing a record 23rd Grand Slam title in Paris, wrote the message in Serbian after his opening-round victory over Aleksandar Kovacevic on Monday.

"Kosovo is our cradle, our stronghold, center of the most important things for our country," 36-year-old Djokovic told Serb media.

His comments came amid heightened ethnic tensions in northern Kosovo where demonstrators and NATO soldiers have been injured.