Novak Djokovic was two wins away from a 22nd Grand Slam crown after bulldozing into the Australian Open semifinals on Wednesday, while Aryna Sabalenka was equally impressive in reaching the women's last four.

Serbia's Djokovic delivered a masterclass to crush Russian fifth seed Andrey Rublev 6-1, 6-2, 6-4 on Rod Laver Arena and set up a meeting with Tommy Paul for a place in Sunday's final.

Djokovic's quest to go level with great rival Rafael Nadal on a leading 22 major titles carries an air of inevitability.

The 35-year-old struggled with a hamstring injury in the early rounds at Melbourne Park but was dominant during his fourth-round demolition of Alex de Minaur and was equally clinical against the outclassed Rublev.

"Last two matches, playing against two guys who were in form and to beat them dominantly in three sets is something that I definitely want in this moment, something that sends a message to all my opponents," said a buoyant Djokovic.

"With this kind of game the confidence level rises, so I feel better on the court as the tournament progresses."

Victory for the red-hot favourite propelled him into a 44th Grand Slam semi-final to close the gap on Roger Federer's all-time record of 46.

Anything other than a rampant win for Djokovic against unseeded Paul would amount to a massive upset, albeit at a tournament that has seen numerous shocks in the men's and women's draws.

Paul defeated his fellow American Ben Shelton 7-6 (8/6), 6-3, 5-7, 6-4 to reach his first major semi-final.

But former world number one Djokovic, who can return to the top of the rankings if he wins the Australian Open for a record-extending 10th time, will be a whole new prospect.

Paul, ranked 35, and the Serb great have never played each other before.

"I saw him in the locker room after I finished my match. He said, 'congrats'," said the 25-year-old, adding they had practised together before.