“Never ever threaten the United States again or you will suffer consequences the likes of which few throughout history have ever suffered.

WASHINGTON — President Donald Trump’s explosive Twitter threat to Iran’s leader comes as his administration is ratcheting up a pressure campaign on the Islamic republic that many suspect is aimaed at regime change.

No one is predicting imminent war. But Trump’s bellicose, all-caps challenge addressed to President Hassan Rouhani followed a speech by Secretary of State Mike Pompeo in which he accused Iran’s leadership of massive corruption and widespread rights abuses and urged Iranians to rise up in protest.

Both the tweet and the speech landed less than two weeks before the administration will begin re-imposing sanctions on Iran that had been lifted under the 2015 nuclear deal. In the meantime, the US is stepping up Farsi-language outreach that is intended to support Iranians demonstrating against the policies of their government.

Trump’s tweet doesn’t appear to have been prompted by any notable shift in rhetoric from Iran.

It could have been an impulsive reaction to reports from Tehran quoting Rouhani as giving the US an oft-repeated reminder that conflict with Iran would be “the mother of all wars.” Yet animosity directed at the Iranian leadership is an established part of the administration’s broader foreign policy.

Iran publicly shrugged off Trump’s late Sunday message — “NEVER EVER THREATEN THE UNITED STATES AGAIN OR YOU WILL SUFFER CONSEQUENCES THE LIKES OF WHICH FEW THROUGHOUT HISTORY HAVE EVER SUFFERED BEFORE.”

Tweeted Foreign Minister Mohammad Javad Zarif on Monday: “COLOR US UNIMPRESSED: The world heard even harsher bluster a few months ago. And Iranians have heard them — albeit more civilized ones — for 40 yrs. We’ve been around for millennia & seen fall of empires, incl our own, which lasted more than the life of some countries. BE CAUTIOUS!”

Asked at the White House if he had concerns about provoking Iran, Trump said simply, “None at all.”

Tehran is already aware of what is coming from the administration as consequences of Trump’s May withdrawal from the 2015 nuclear accord take shape.

As Pompeo noted in his speech to Iranian-Americans and others in California on Sunday, the centerpiece will be the re-imposition of US economic sanctions; the first batch will go back into force 4 August, targeting the Iranian automotive sector and trade in gold and other metals. A more significant set of sanctions that will hit Iran’s oil industry and central bank by punishing countries and companies that do business with them will resume 4 November.

“Right now, the United States is undertaking a diplomatic and financial pressure campaign to cut off the funds that the regime uses to enrich itself and support death and destruction,” Pompeo said in his speech at the Ronald Reagan Presidential Library and Museum in Simi Valley.

“We’ve been around for millennia and seen fall of empires. Be cautious.

Pompeo also slammed Iran’s political, judicial and military officials, accusing several by name of participating in rampant corruption and called its religious leaders “hypocritical holy men” who amassed wealth while allowing their people to suffer. He said the government has “heartlessly repressed its own people’s human rights, dignity and fundamental freedoms,” and he hailed the “proud Iranian people (for) not staying silent about their government’s many abuses.”

“The United States under President Trump will not stay silent either,” he said.

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