Researchers at the University of the Philippines Manila (UP Manila) have made a significant breakthrough in the treatment of solvent addiction, potentially paving the way for more effective and affordable therapies.

The findings, published in the international journal Psychopharmacology last 18 December 2024, stemmed from a three-year research program funded by the Department of Science and Technology.

Titled “Novel Approaches to Treatment of Addiction and Depression using Animal Models,” the program investigates the effects of chronic exposure to inhalants, particularly toluene, on adolescent brains.

Toluene, a common solvent found in paints, thinners, glues, nail polish, gasoline, and waterproof adhesives, can have devastating effects on cognitive function and social behavior.

Through a series of experiments on rats, researchers observed that chronic exposure to toluene led to impaired decision-making and social withdrawal.

“This will allow us to develop treatments that are equally effective in both sexes,” said Dr. Rohani Cena-Navarro, program leader. “The use of rats allows us to examine the effects of abused drugs on the brain. Our goal is to reverse these effects so as to restore the brain to its normal state.”

The study highlights the significant impact of solvent abuse on adolescent development.

“Because addiction has been established as a brain disorder, the clinician can tell the patient, ‘You are not weak. The chemical compound rewires the brain and impairs its decision-making process,’” Cena-Navarro said.

“Rehabilitating the adolescent brain can end the cycle of addictive behavior and relapse so that young people can restore their relationships and plan for the future,” she added.